Jon Garland (5-2) struck out four and walked two in five innings, allowing four runs on nine hits in the first game of a two-game series between the Padres and the Dodgers.
Chase Headley added a solo homer for the Padres, who ended LA's nine-game winning streak.
Ramon Ortiz lasted just 3 1/3 innings, surrendering five runs on six hits to fall to 1-2.
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