Morales' first clout was a three-run blast in the fourth inning that erased a 2-0 Oakland lead and put the Angels up for good. His second homer was a two-run shot in the seventh inning.
Ervin Santana (2-3) lasted six innings to pick up the victory, holding the A's to two earned runs on seven hits over six innings, walking three and striking out six.
Tyson Ross (1-1) was roughed up for three runs in 3 2/3 innings, and the Oakland bullpen was pounded for nine runs on 12 hits.
Eric Patterson homered and collected three hits in the A's loss.