Borel became the first jockey in Derby history to accomplish the feat, while prominent trainer Todd Pletcher got his first win of the fabled horse race.
Borel maneuvered Super Saver -- who came off at 8-1 as the second-betting favorite -- along the rail on the rain-soaked track to finish ahead of 11-1 Ice Box and 12-1 Paddy O'Prado with a winning time of 2:04 2/5ths on the 1 1/4-mile Churchill Downs track.
A steady, daylong rain in Louisville ended and the sun came out moments before the 6:32 p.m. post time.
With the win, the colt continued a comeback from a highly anticipated but disappointing 2010 debut when he could manage only a third-place finish in the Tampa Bay Derby, the Louisville Courier-Journal reported.
Super Saver, of WinStar Farms, improved earlier this month when he finished second at the Arkansas Derby at Oaklawn Park, outgunned by a neck down the stretch of that race by Line of David, the newspaper said.
The sixth-largest crowd in Derby history, some 155,804, attended the event despite the inclement weather.