Colorado got a pair of RBIs from Troy Tulowitzki and six solid innings from Ubaldo Jimenez (2-0), who allowed only one earned run. Jimenez struck out seven and walked three while Franklin Morales finished up with a perfect ninth to notch his second save of the year.
The Padres were led by Will Venable, who collected a pair of hits and an RBI in San Diego's fourth setback in six games to start the season.
Jon Garland (0-2) was saddled with the loss after allowing four runs on eight hits over six innings.
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