Garcia-Lopez ousted Granollers 6-3, 6-2, moving past the second round of a tournament for only the second time this year. He will face No. 8 Florent Serra in the quarterfinals after Serra defeated Stephane Robert 2-6, 6-1, 6-3.
In the other half of the draw, fourth-seeded Lukasz Kubot and Potito Starace set up a quarterfinal meeting.
Kubot won over Arnaud Clement 6-4, 6-1 and Starace was a 6-2, 6-1 winner over Oscar Hernandez.
Stanislas Wawrinka, seeded No. 1 in the tournament, will face Martin Klizan Thursday in the second round.