Wade dished off 12 assists and hauled down seven rebounds for Miami, which won its fifth game in seven contests. The Heat got a 16-point effort from Michael Beasley.
The Nets fell to 7-63 for the season, inching closer to the NBA's all-time worst record of 9-73 turned in by the 1972-73 Philadelphia 76ers.
Brook Lopez pumped in 26 points while Devin Harris ended with 16 points and six assists in New Jersey's eighth straight loss.
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