Washington, seeded 11th, also got 15 points and eight rebounds from Matthew Bryan-Amaning in posting its ninth straight win and extending its record to 14-2 since Jan. 26.
The Huskies (26-9) benefitted from Isaiah Thomas's four 3-pointers en route to a 15-point performance while distributing 7 assists. Elston Turner contributed 10 points off the bench for Washington, which will be making its fifth Sweet 16 appearance.
The third-seeded Lobos (30-5) were led by Dairese Gary with 25 points while Darington Hobson donated 11 points and nine boards in the loss.
After sneaking past 14-seeded Montana Thursday, New Mexico kept its record of never having won two straight NCAA Tournament games intact.