Mike Singletary added 13 points for the Red Raiders and D'walyn Roberts recorded a double-double with 12 points and 11 rebounds.
Texas Tech will face the winner of Tuesday's Arizona State-Jacksonville game.
Jeff Robinson had a big night for the Pirates with 23 points and a dozen rebounds. Jordan Theodore scored 13 points and Eugene Harvey added 12.
The Red Raiders led 45-32 at halftime after shooting 54.5 percent from the field. They held Seton Hall to a 35.7-percent shooting mark in the second half.
Free throws played a significant role in the outcome with Texas Tech converting 22-of-32 shots and the Pirates hitting 8-of-11 from the line.
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