Holmes also picked up a technical foul as heated words were exchanged in the first half. Oklahoma State's Marshall Moses also was slapped with a first-half technical foul.
The Cowboys (20-9, 8-7) were led by James Anderson with 27 points while Obi Muonelo chipped in with 13 as Oklahoma State ended a four game span against ranked opponents with a 2-2 record.
Lytro unveils camera that can focus a photo after shooting it
'How to Train Your Dragon 2' releases 5-minute clip