The trio's losses followed Wednesday's exit of No. 1 overall seed Steve Stricker at the Ritz-Carlton Golf Club in Marana, Ariz.
Furyk had the best showing of the three, rebounding to all-square in his match against No. 9 Charl Schwartzel before ultimately falling by a 3 & 2 score.
The No. 2 seeds also have struggled. Paul Casey was the only second seed to emerge with a win, while Padraig Harrington lost Wednesday, Henrik Stenson conceded while suffering from the flu and Rory McIlroy lost a close match to Oliver Wilson Thursday in extra holes.