Ferrero, a former world No. 1 player from Spain, took down Marcos Daniel of Brazil 6-2, 6-4.
Spain's Albert Montanes, the fifth seed, also had a dominating win, defeating countryman Pablo Andujar 6-3, 6-2.
David Nalbandian of Argentina, who won the tournament in 2008, dropped the opening set but came back to down Spaniard Daniel Gimeno-Traver 6-7 (5-7), 6-4, 7-6 (9-7).
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