He won the event at the Daytona International Speedway after Michael Waltrip's late crash led to a wild finish at the green-white-checkered flag.
Harvick, who arrived late Friday after driving from his North Carolina home, where he battled flu-like symptoms, became the fourth driver to win the Sprint Cup's lone non-points event in consecutive years.
The others are Neil Bonnett (1983-84), Ken Schrader (1989-90) and Tony Stewart (2001-02).
"I got to thank my team," Harvick said. "They did a great job (and) I was sick on Thursday."
Kasey Kahne, Jamie McMurray, Kyle Busch, and Denny Hamlin finished in spots 2-5, while reigning points champion Jimmie Johnson was 13th.
Carl Edwards led the most laps (42).