DeMarcus Cousin had a double-double with 16 points and 14 rebounds for Kentucky (19-0, 4-0 SEC), which appears poised to take over the top ranking since current No. 1 Texas was upset by Connecticut Saturday. John Wall and Eric Bledsoe also were in double figures with 16 and 10, respectively.
The Razorbacks (8-11, 1-3) got 21 points from Courtney Fortson, 13 from Rotnei Clarke and 11 from Mike Washington.
The Wildcats, who held Arkansas to just 30.6 percent shooting from the field, jumped to a 15-3 lead at the onset and 57-27 at halftime before starting the second half with an 18-2 run.
The Wildcats, the only undefeated major college left this season, are off to their best start since the 1966 season.