The Pistons lost their 11th game in a row.
The Spurs had only a two-point lead to open the final period, but made 15-of-20 shots from the field during those 12 minutes and outscored the Pistons 35-17.
The losing streak is Detroit's longest since the 1993-94 season, when the Pistons dropped 13 straight.
Detroit was led by 29 points from Richard Hamilton.
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