The Blues, who earlier Saturday fired head Coach Andy Murray and took the ice with interim head coach Davis Payne behind the bench, had goals from Andy McDonald, Keith Tkachuk and Eric Brewer. Ty Conklin allowed six goals on 33 shots.
St. Louis tied the game twice in the first period, but did not score again until Tkachuk scored on a power play with 2:08 left to play.
After the first period ended in a 2-2 tie, Chicago scored twice in the second and twice in the third to take a 6-2 lead into the home stretch.
2014: The Year in Music [PHOTOS]