The win gave the Falcons (9-7) the first back-to-back winning seasons in the 44-year history of the franchise.
Ryan finished with 23 completions in 35 attempts for 223 yards with two interceptions.
Tampa Bay (3-13) scored on an 8 -yard pass from Josh Freeman to Antonio Bryant and a 46-yard field goal by Connor Barth.
Freeman was 16-of-32 for 172 yards and also was intercepted twice.
The season is over for both teams.
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