Middleton scored 17 points to go with seven rebounds.
Texas A&M led by only nine at halftime, but put together a 14-4 run early in the second period to take control. The Aggies shot 50 percent from the field and made 12-of-31 from 3-point range while improving to 6-1.
Michael Griffin scored 16 for the Panthers (3-3).
It was the 59th straight home win for the Aggies against non-conference opponents.