Brees, in his ninth NFL season, made the Saints 11-0 Monday night for the first time in franchise history, completing 18-of-23 passes for 371 yards in their 38-17 victory.
He is the second player in league history to pass for at least 350 yards and complete at least 75 percent of his passes with no interceptions in a single contest, joining Patriots quarterback Tom Brady.
Also garnering NFC honors were Green Bay cornerback Charles Woodson (Defense) and Arizona kick returner La Rod Stephens-Howling (Special Teams).
Woodson became the first player in NFL history with two interceptions, an interception-return touchdown, one sack, a forced fumble and a fumble recovery in the Packers 34-12 win at Detroit.
Stephens-Howling had a 99-yard kick-return touchdown and downed punts at the five-, two- and one-yard lines in the Cardinals' 20-17 loss at Tennessee.