New Jersey has lost all of its 15 games this season and is within two defeats of equaling the longest skid to start a campaign in NBA history. Both Miami and the Los Angeles Clippers have opened a season with 17 straight setbacks.
The Nets battled their way into a third-period tie but Portland scored eight in a row en route to its third straight victory.
New Jersey next plays in Sacramento Friday and then must face the Los Angeles Lakers Sunday.
Brandon Roy added 13 for Portland while both Rudy Fernandez and LaMarcus Aldridge had 12.
The Nets were led by a career-high 32 points from Brooke Lopez.