The play, one of three OSU interceptions, gave the winners a 24-10 advantage with 8:06 left in the fourth quarter.
They held a 243-50 advantage in rushing yards.
Zac Robinson had 90 passing yards and 99 rushing.
Perrish Cox had two interceptions.
Keith Toston gained 76 yards on 22 carries, while Kendall Hunter had 90 all-purpose yards for the Cowboys (8-2, 5-1), who have won seven of eight.
TTU's Taylor Potts completed 19-of-35 passes for 190 yards, one touchdown and one interception.
Steven Sheffield went 16-for-23 for 117 yards and one touchdown, but threw two interceptions.
Edward Britton and Alex Torres caught scoring passes, while Detron Lewis had six receptions for 75 yards for the Red Raiders (6-4, 3-3), who have lost two of three.