Kansas extended the nation's longest home-court winning streak to 42 games.
The Jayhawks will be trying to win their sixth straight Big 12 Conference title this season and will be favored to do so since they return their top nine scorers and all five starters.
They went 27-8 last season and lost in the third round of the NCAA Tournament to eventual runner-up Michigan State.
Charles Jenkins scored 23 points to lead Hofstra, which is coming off a 21-11 campaign.
2014: The Year in Fashion [PHOTOS]
UPI Sports Results for September 19, 2014