Bryant was declared ineligible by Oklahoma State officials on Oct. 7 for allegedly failing to fully disclose to NCAA investigators contact with former NFL player Deion Sanders.
The NCAA later barred Bryant, a junior, from returning this season and took away a season of eligibility. Bryant appealed but an NCAA committee Thursday upheld the penalties.
Bryant caught 17 passes for 323 yards and four touchdowns in the three games before his suspension. He was a consensus All-American at wide receiver last season as a sophomore when he caught 87 passes for 1,480 yards and 19 touchdowns.
He will be eligible to enter the NFL Draft next year.