In a stirring battle of Frenchmen, Llodra rallied to force a tie-break in the third set, then dominated the tie-break before ending the match with a powerful forehand to set up a final Sunday against third-seeded Ivan Ljubicic of Croatia.
"I feel like my serve is working very well, and also my volleying as well," Llodra said. "I'm trying to put a lot of pressure on my opponents, and taking away the rhythm."
Ljubicic, a 6-2, 6-4 over former Lyon champion Arnaud Clement of France, won his first title in eight career finals at Lyon in 2001.
His last title was in June 2007 at 's-Hertogenbosch, Netherlands.
Sunday's Llodra-Ljubicic winner makes $152,000.