Philadelphia's second-round pick in the 2008 NFL Draft out of California scored on a 67-yard run and a 57-yard reception, leading the Eagles to a 27-17 win at Washington on Monday Night Football.
Jackson is third player in league history with touchdowns of 50-plus yards receiving and rushing touchdown in the same game, joining Washington's Clinton Portis and Chris Johnson of the Tennessee Titans.
He was joined in the NFC by Arizona safety Adrian Wilson (defense) and Dallas wide receiver/kick returner Patrick Crayton (special teams).
Wilson made five tackles, two for a loss, an interception and a fumble recovery in the Cardinals' 24-17 win over the New York Giants.
Crayton had 73-yard punt-return touchdown and a five-yard touchdown catch in the Cowboys' 37-21 win over the Atlanta Falcons.