Briere scored the opening goal for the host Flyers in the first period and then added a power-play goal at 5:03 of the third period to put Philadelphia ahead 4-1.
Florida goalie Tomas Vokoun was peppered with 38 shots. David Booth scored the lone Panthers goal in the first period. He was later taken from the ice on a stretcher after being knocked unconscious on a bruising hit at center ice in the second by Flyers captain Mike Richards.
Booth was taken to a hospital for treatment while Richards, who had two assists in the game, was sent off with a five-minute major for interference and a 10-minute game misconduct penalty.