Brees completed 15 straight passes during one stretch and finished 23-of-30 for 369 yards.
Eli Manning was 14-of-31 for 178 yards and a touchdown with one interception for the Giants (5-1). The scoring toss was a 15-yarder to Mario Manningham.
David Carr, who replaced Manning late in the game, passed for 72 yards, including a 37-yard scoring strike to Hakeem Nicks.
Ahmad Bradshaw ran 10 yards for a New York score.
Man spent 15 hours in jail for plugging electric car into an outlet at a school
Martin Bashir resigns from MSNBC over Sarah Palin comments