Brees completed 15 straight passes during one stretch and finished 23-of-30 for 369 yards.
Eli Manning was 14-of-31 for 178 yards and a touchdown with one interception for the Giants (5-1). The scoring toss was a 15-yarder to Mario Manningham.
David Carr, who replaced Manning late in the game, passed for 72 yards, including a 37-yard scoring strike to Hakeem Nicks.
Ahmad Bradshaw ran 10 yards for a New York score.
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