The five scoring passes in the second tied a 59-year-old NFL record for a single quarter and the margin of victory was the greatest in the league since 1976.
Laurence Maroney carried 16 times for 123 yards and a touchdown for the Patriots (4-2).
Kerry Collins completed only 2-of-12 passes for minus seven yards, was intercepted once and lost a fumble for the Titans (0-6).
Chris Johnson gained 128 yards rushing for Tennessee, which has lost seven straight games going back to last season.
Swim Week Miami Beach 2014 [PHOTOS]