The five scoring passes in the second tied a 59-year-old NFL record for a single quarter and the margin of victory was the greatest in the league since 1976.
Laurence Maroney carried 16 times for 123 yards and a touchdown for the Patriots (4-2).
Kerry Collins completed only 2-of-12 passes for minus seven yards, was intercepted once and lost a fumble for the Titans (0-6).
Chris Johnson gained 128 yards rushing for Tennessee, which has lost seven straight games going back to last season.
Ray Liotta sues skin care company over use of likeness
Kim Kardashian, Kanye West reportedly set wedding date