Clark completed 21-of-32 passes for 287 yards and his 12-yard touchdown pass to Derek Moye gave PSU a 13-0 lead with 35 seconds left in the second quarter.
His 1-yard touchdown run capped the scoring with 1:41 left in the third.
Evan Royster rushed for 137 yards on 23 carries, while Collin Wagner added two field goals for the Nittany Lions (6-1, 2-1 Big Ten), who have won three in a row since a 21-10 loss to Iowa on Sept. 26.
Minnesota quarterback Adam Weber went 10-for-22 for 101 yards and one interception, but the Gophers (4-3, 2-2) gained only 37 net rushing yards in their second loss in the last three games.
Notable deaths of 2014 [PHOTOS]