Rashard Mendenhall ran for 77 yards, including a 7-yard touchdown, for Pittsburgh (3-2).
The Lions (1-4) scored on a 25-yard pass from Daunte Culpepper to Dennis Northcutt with 4:57 remaining and got deep into Pittsburgh territory on a subsequent drive before the Steelers sacked the quarterback on three straight plays.
Pittsburgh totaled seven sacks, three by James Harrison.
Culpepper completed 23-of-37 passes for 282 yards and was intercepted once.
Williams James picked off a pass and ran 38 yards for a touchdown for the Lions.
Notable deaths of 2014 [PHOTOS]