A week earlier, Brees threw six touchdown passes in a 45-27 Saints win over Detroit.
Mike Bell ran for 86 yards and a score for New Orleans (2-0).
Kevin Kolb, starting in place of the injured Donovan McNabb, was 31-of-51 for 391 yards and two touchdowns for the Eagles (0-1). The Saints picked off three of Kolb's passes.
DeSean Jackson caught four passes for 101 yards and a touchdown and Brent Celek had eight catches for 104 yards for Philadelphia.
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