Ray Rice caught five passes for 82 yards for Baltimore (2-0).
Philip Rivers completed 25-of-45 passes for 436 yards and two scores for the Chargers (1-1). Rivers, who was intercepted twice, connected with Darren Sproles on an 81-yard touchdown pass and with Vincent Jackson on a 35-yard TD.
Nate Kaeding booted four field goals, the longest from 29 yards, for San Diego.
Handler slams Piers Morgan: 'You're a terrible interviewer'
Beautician charged with giving client fatal silicone butt injection