The Chargers have now beaten the Raiders 12 times in a row.
Philip Rivers connected on 24-of-36 passes for 252 yards with one score and an interception for San Diego (1-0).
LaDainian Tomlinson also scored and tallied 55 yards on 13 carries.
Russell connected on just 12-of-30 passing for 208 yards and was intercepted twice for Oakland (0-1).
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