Hayward is expected to have season-ending surgery Friday. Jaguars Coach Jack Del Rio said the injury is not career-ending.
This is the second time Hayward has suffered such an injury in the opening weekend of a season. He tore his Achilles tendon in the first week of 2006.
Hayward played in all 16 games last season for the first time since 2004, recording 4 1/2 sacks and two forced fumbles.
In his nine-year career with Denver and Jacksonville, Hayward has 39 1/2 sacks, one interception and seven forced fumbles in 92 games.