Ryan made the announcement at a news conference, saying he decided to open the season with Sanchez, the fifth overall pick in the 2009 NFL Draft in June out of Southern California, instead of four-year veteran Kellen Clemens.
"That's not a slight to Kellen Clemens at all," Ryan told reporters. "I think we can win with Kellen, also as a quarterback (but) right now I think Mark gives us the best opportunity to win. This was strictly my decision. I think (Sanchez) has everything, all of the things you look for."
Sanchez completed 5-of-10 passes for 43 yards with one touchdown and an interception in Monday's 24-23 pre-season loss to the Baltimore Ravens.
Notable deaths of 2014 [PHOTOS]