De La Hoya, 36, was nicknamed the "Golden Boy" and ends his career with a 39-6-0 record with 30 knockouts. He was considered one of the best pound-for-pound boxers of his time.
His last fight was Dec. 6 when he was beaten by Manny Pacquiao.
"Every time I stepped inside the ring, I gave it my best," De La Hoya said. "I'm looking forward to continuing to be the best outside the ring. That is just as important as everything I've accomplished inside the ring."
De La Hoya won an Olympic gold medal for the United States in 1992 and picked up his first professional title in 1994 with a WBO super featherweight win over Jimmi Bredahl. His last championship was won in May 2006 when he returned from a 20-month layoff and beat Ricardo Mayorga for the WBC light middleweight title.
He also won championships in lightweight, light welterweight, welterweight and middleweight classes.