The Lakers clinched the No. 1 seed in the Western Conference by winning their fifth in a row and eighth out of nine games.
Gasol added 11 rebounds while Derek Fisher added 18 points. Bryant, who averages 27 points a game, made just 5-of-19 shots from the field and scored 14.
New Jersey lost its third straight and fell four games out of the final playoff position in the Eastern Conference. Vince Carter led the Nets with 20 points.