Terrence Williams had 11 points, seven rebounds, six assists and seven steals for the Cardinals (28-5), who also won the Big East regular-season championship.
Samardo Samuels scored 15 points, Earl Clark had 13 and Preston Knowles 12 for Louisville, which overcame an eight-point halftime deficit for its 10th straight win.
Syracuse (26-9) had a tough tournament. The Orange needed six overtimes to beat fourth-ranked Connecticut in the quarterfinals and one overtime session to beat West Virginia in the semifinals.
Eric Devendorf led Syracuse with 20 points.