Perez closed his round with an eagle on the final hole, finishing the five-round event at 33-under 327, three shots ahead of John Merrick, who had a 67.
Steve Stricker, who had led after the fourth round, fell to a 5-over 77 and tied for third place with Mike Weir (67), the 2003 champion, at 28-under 332. Stricker's round included triple and quadruple bogeys.
Perez led Merrick by one stroke before hitting his second shot to within 2 feet and rolling in the putt for the eagle on the 18th.
"It's just awesome," Perez said, describing his win.
Britney Spears on kissing Ryan Gosling, Justin Timberlake in the Mickey Mouse Club
Exploding whale video goes viral on Internet