It was Nabokov's second shutout this season and 42nd of his NHL career.
San Jose is now 18
All five Sharks goals came on just 15 shots against Canucks netminder Cory Schneider, who was lifted for Curtis Sanford, who stopped all 16 shots he faced the rest of the way.
Vancouver dropped its second game in its last three.
The Sharks quickly put things out of reach for the Canucks, scoring three times in the first period. Blake scored first on a wrist shot at the 4:22 mark.
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