Deuce McAllister rushed for a touchdown and established a Saints career record of 54 touchdowns. The Saints' point total equaled a franchise record for one game.
Lance Moore caught five passes for 115 yards and two scores for New Orleans (6-5), which is two games out of first place in the NFC South behind Tampa Bay and Carolina, who are tied for the division lead.
Pierre Thomas rushed for 87 yards and two TDs for the Saints.
Aaron Rodgers went 23-of-41 passing for 248 yards and two TDs, but he also threw three interceptions.
Greg Jennings caught eight passes for 101 yards and a touchdown for the Packers (5-6), who have lost three of their last four games and trail Chicago and Minnesota by one game for the NFC North lead.