Manning was 17-of-31 passing for 191 yards. He connected with Plaxico Burress on a 17-yard scoring pass in the first quarter and hit Kevin Boss for a 1-yard TD in the second.
Jacobs ran for 126 yards and scored on two 3-yard runs and John Carney booted three field goals for the Giants (8-1).
Donovan McNabb completed 17-of-36 passes for 194 yards and three touchdowns for the Eagles (5-4).
New York leads the NFL East by two games over second-place Washington.