Kerry Collins threw for 193 yards on 24-of-37 passing, without a touchdown or interception, for the Titans (7-0), who have won the first seven games of the season for the first time in franchise history.

Dating back to Dec. 16 of last season, Tennessee has 10 consecutive regular season wins, the longest current streak in the NFL.

Rob Bironas added three field goals for the Titans.

Peyton Manning threw for 223 yards and two touchdowns on 26-of-41 passing, but was intercepted twice for the Colts (3-4), who have lost two in a row and are tied with Jacksonville and Houston at the bottom of the division.

Dallas Clark caught both TD passes from Manning in a seven-reception, 94-yard effort.