Sutherland, who has won just one PGA Tour title, completed 54 holes at 14-under- par 196, which established the tournament's 54-hole scoring record by one stroke.
Sutherland, 44, has the 54-hole lead for the third time in his PGA Tour career. The other two times -- at the 1997 Houston Open and the 2007 Pebble Beach National Pro-Am -- he finished second.
George McNeill had a 4-under 66 to move into second place at 13-under 197. Paul Goydos (66), Steve Allan (68) and John Mallinger (66) are tied for third place at 198.