Daniel completed 31-of-37 passes for Missouri (6-2, 2-2 Big 12), which was coming off consecutive losses to Oklahoma State and Texas.
Jeremy Maclin had 11 receptions for 134 yards and two touchdowns and Chase Coffman and Tommy Saunders each had a touchdown catch. Derrick Washington ran for 83 yards and one touchdown on 17 carries.
Cody Hawkins struggled for Colorado (4-4, 1-3), throwing for just 86 yards on 9-of-17 passing before giving way to Tyler Hansen. Hansen connected on 12-of-16 pass attempts for 72 yards.
Scotty McKnight caught four passes for 44 yards and Colorado rushed for only 41 yards for the game, finishing with just 199 yards of total offense.
The Tigers posted their first shutout of Colorado since 1962, when Missouri defeated the Buffaloes 57-0.