Manning started his best effort this season with a 67-yard first-quarter touchdown pass to Marvin Harrison, and finished with 19 completions on 28 pass attempts for 271 yards.

Harrison scored twice on just three receptions for 83 yards, and wideout Reggie Wayne scored once on eight receptions for 118 yards for the 3-2 Colts, who lost starting tailback Joseph Addai to a first-quarter hamstring injury.

Baltimore rookie quarterback Joe Flacco completed 28-of-38 passes for 241 yards, but was plagued by three interceptions.

Wide receiver Derrick Mason caught six passes for 70 yards.

Backup running back Ray Rice gained 64 yards on seven receptions, but starter Willis McGahee was held to 18 yards on eight carries for the Ravens (2-3), who have lost three games in a row.