Daniel's third scoring pass helped Missouri build a 52-10 advantage with 1:32 left in the third quarter, one play after the Missouri defense recovered a fumble.
Daniel completed 18-of-23 passes for 252 yards.
Wide receiver Jeremy Maclin caught a 58-yard first quarter scoring pass. He finished with five catches for 88 yards and 56 yards on two kickoff returns.
Derrick Washington gained 140 yards on 10 carries, two for touchdowns, and Brock Christopher scored on a 17-yard third-quarter interception return for the Tigers (5-0, 1-0 Big 12).
Missouri has won four of its last six games against Nebraska.
Nebraska quarterback Joe Ganz tossed two touchdown passes and completed 26-of-38 passes for 294 yards. Jeff Wolfert kicked a 48-yard second-quarter field goal for the Cornhuskers (3-2, 0-1), who still lead the series by a 63-36-3 margin.