Eagles rookie DeSean Jackson contributed 203 total yards -- 106 on six receptions and 97 on eight punt returns.
McNabb was 21-of-33 passing for 361 yards and Brian Westbrook rushed for 91 yards and a touchdown for Philadelphia.
Hank Baskett scored on a 90-yard pass play for the Eagles (1-0), who accumulated 522 yards to 166 for the Rams.
Notable deaths of 2014 [PHOTOS]
Julius Randle breaks leg during NBA debut