Quarterback Chris Todd completed 21 of 31 passes for 248 yards for Auburn (2-0). Tate rushed for 71 yards and had three receptions for 51 yards.
Shawn Nelson caught 12 passes for 118 yards and one touchdown for Southern Mississippi (1-1). Austin Davis, who completed 33 of 50 passes for 268 yards, passed for two touchdowns and was intercepted twice.
Wes Byrum kicked two field goals for Auburn, the first a 52-yarder.