Santana (14-5) struck out seven, one outing after he had fanned 10 men in a no-decision against Minnesota.

Francisco Rodriguez worked a perfect ninth for his 52nd save.

Texas held a 1-0 lead going into the sixth, but Chone Figgins came up with a one-out single and scored on Garret Anderson's 14th homer of the year.

The go-ahead runs came off Dustin Nippert (1-4).

After Anderson put the Angels in front, Mark Teixeira continued the inning with a single, moved around to third on walks to Vladimir Guerrero and Torri Hunter and scored on Juan Rivera's sacrifice fly.