The defending Super Bowl champion Giants had to hang on for the victory when the Browns scored 10 points in the fourth quarter to get within three.
Manning was 4-for-7 passing for 52 yards and the two scoring strikes to Hixon -- who also returned a kickoff 82 yards for a score. Danny Ware gained 97 yards on 10 rushes and Ahmad Bradshaw ran for a 1-yard touchdown for New York.
Browns' starting quarterback Derek Anderson was 4-of-10 passing for 20 yards before leaving the game in the second quarter after a hard hit by Osi Umenyiora. Brady Quinn completed 7-of-12 passes for 124 yards and a 44-yeard touchdown pass to Syndric Steptoe, who picked up 80 yards on three catches and scored on a seven-yard run for Cleveland.
Ken Dorsey threw for 143 yards and an eight-yard touchdown strike to Lance Leggett for the Browns.